ErbB-2 Receptor

A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.

Also Known As:

Receptor, ErbB-2; Antigens, CD340; CD340 Antigen; Erb-b2 Receptor Tyrosine Kinases; Metastatic Lymph Node Gene 19 Protein; Neu Receptor; Oncogene Protein HER-2; Proto-Oncogene Proteins c-erbB-2; Proto-oncogene Protein Neu; Receptor, Neu; Receptors, erbB-2; Tyrosine Kinase-type Cell Surface Receptor HER2; p185(c-neu); p185erbB2 Protein; CD340 Antigens; Erb b2 Receptor Tyrosine Kinases; HER 2 Proto Oncogene Protein; Oncogene Protein HER 2; Proto Oncogene Protein HER 2; Proto Oncogene Proteins c erbB 2; Proto-Oncogene Protein, HER-2; Proto-Oncogene Protein, erbB-2; Proto-Oncogene Protein, neu; Tyrosine Kinase type Cell Surface Receptor HER2; c erbB 2 Protein; erbB 2 Proto Oncogene Protein; erbB 2 Receptor Protein Tyrosine Kinase; erbB-2 Receptors; neu Proto Oncogene Protein; HER-2 Proto-Oncogene Protein; Proto-Oncogene Protein HER-2; Proto-Oncogene Protein p185(neu); c-erbB-2 Protein; erbB-2 Proto-Oncogene Protein; erbB-2 Receptor Protein-Tyrosine Kinase; neu Proto-Oncogene Protein

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        ErbB Receptors: 27986
        ErbB-2 Receptor: 526
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        ErbB Receptors: 27986
        ErbB-2 Receptor: 526
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        ErbB Receptors: 27986
        ErbB-2 Receptor: 526
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        ErbB Receptors: 27986
        ErbB-2 Receptor: 526
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        ErbB-2 Receptor: 526
Biological Factors: 2472
- Biomarkers: 240291
  - Tumor Biomarkers: 15272
    - ErbB-2 Receptor: 526
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - Minor Histocompatibility Antigens: 395
        ErbB-2 Receptor: 526
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - Minor Histocompatibility Antigens: 395
        ErbB-2 Receptor: 526

J H Piekarski Selected Research

J H Piekarski Research Topics

Disease

Drug/Important Bio-Agent (IBA)

Therapy/Procedure